Compassionate Use of Remdesivir for Patients with Severe Covid-19
Identifieur interne : 000802 ( 2020/Analysis ); précédent : 000801; suivant : 000803Compassionate Use of Remdesivir for Patients with Severe Covid-19
Auteurs : Jonathan Grein ; Norio Ohmagari ; Daniel Shin ; George Diaz ; Erika Asperges ; Antonella Castagna ; Torsten Feldt ; Gary Green ; Margaret L. Green ; François-Xavier Lescure ; Emanuele Nicastri ; Rentaro Oda ; Kikuo Yo ; Eugenia Quiros-Roldan ; Alex Studemeister ; John Redinski ; Seema Ahmed ; Jorge Bernett ; Daniel Chelliah ; Danny Chen ; Shingo Chihara ; Stuart H. Cohen ; Jennifer Cunningham ; Antonella D Rminio Monforte ; Saad Ismail ; Hideaki Kato ; Giuseppe Lapadula ; Erwan L Er ; Toshitaka Maeno ; Sumit Majumder ; Marco Massari ; Marta Mora-Rillo ; Yoshikazu Mutoh ; Duc Nguyen ; Ewa Verweij ; Alexander Zoufaly ; Anu O. Osinusi ; Adam Dezure ; Yang Zhao ; Lijie Zhong ; Anand Chokkalingam ; Emon Elboudwarej ; Laura Telep ; Leighann Timbs ; Ilana Henne ; Scott Sellers ; Huyen Cao ; Susanna K. Tan ; Lucinda Winterbourne ; Polly Desai ; Robertino Mera ; Anuj Gaggar ; Robert P. Myers ; Diana M. Brainard ; Richard Childs ; Timothy FlaniganSource :
- The New England Journal of Medicine [ 0028-4793 ] ; 2020.
Abstract
Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, has shown in vitro activity against SARS-CoV-2.
We provided remdesivir on a compassionate-use basis to patients hospitalized with Covid-19, the illness caused by infection with SARS-CoV-2. Patients were those with confirmed SARS-CoV-2 infection who had an oxygen saturation of 94% or less while they were breathing ambient air or who were receiving oxygen support. Patients received a 10-day course of remdesivir, consisting of 200 mg administered intravenously on day 1, followed by 100 mg daily for the remaining 9 days of treatment. This report is based on data from patients who received remdesivir during the period from January 25, 2020, through March 7, 2020, and have clinical data for at least 1 subsequent day.
Of the 61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). Of the 53 patients whose data were analyzed, 22 were in the United States, 22 in Europe or Canada, and 9 in Japan. At baseline, 30 patients (57%) were receiving mechanical ventilation and 4 (8%) were receiving extracorporeal membrane oxygenation. During a median follow-up of 18 days, 36 patients (68%) had an improvement in oxygen-support class, including 17 of 30 patients (57%) receiving mechanical ventilation who were extubated. A total of 25 patients (47%) were discharged, and 7 patients (13%) died; mortality was 18% (6 of 34) among patients receiving invasive ventilation and 5% (1 of 19) among those not receiving invasive ventilation.
In this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use remdesivir, clinical improvement was observed in 36 of 53 patients (68%). Measurement of efficacy will require ongoing randomized, placebo-controlled trials of remdesivir therapy. (Funded by Gilead Sciences.)
Url:
DOI: 10.1056/NEJMoa2007016
PubMed: NONE
PubMed Central: 7169476
Affiliations:
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Green</name></author><author><name sortKey="Lescure, Francois Xavier" sort="Lescure, Francois Xavier" uniqKey="Lescure F" first="François-Xavier" last="Lescure">François-Xavier Lescure</name></author><author><name sortKey="Nicastri, Emanuele" sort="Nicastri, Emanuele" uniqKey="Nicastri E" first="Emanuele" last="Nicastri">Emanuele Nicastri</name></author><author><name sortKey="Oda, Rentaro" sort="Oda, Rentaro" uniqKey="Oda R" first="Rentaro" last="Oda">Rentaro Oda</name></author><author><name sortKey="Yo, Kikuo" sort="Yo, Kikuo" uniqKey="Yo K" first="Kikuo" last="Yo">Kikuo Yo</name></author><author><name sortKey="Quiros Roldan, Eugenia" sort="Quiros Roldan, Eugenia" uniqKey="Quiros Roldan E" first="Eugenia" last="Quiros-Roldan">Eugenia Quiros-Roldan</name></author><author><name sortKey="Studemeister, Alex" sort="Studemeister, Alex" uniqKey="Studemeister A" first="Alex" last="Studemeister">Alex Studemeister</name></author><author><name sortKey="Redinski, John" sort="Redinski, John" uniqKey="Redinski J" first="John" last="Redinski">John Redinski</name></author><author><name sortKey="Ahmed, Seema" sort="Ahmed, Seema" uniqKey="Ahmed S" first="Seema" last="Ahmed">Seema Ahmed</name></author><author><name sortKey="Bernett, Jorge" sort="Bernett, Jorge" uniqKey="Bernett J" first="Jorge" last="Bernett">Jorge Bernett</name></author><author><name sortKey="Chelliah, Daniel" sort="Chelliah, Daniel" uniqKey="Chelliah D" first="Daniel" last="Chelliah">Daniel Chelliah</name></author><author><name sortKey="Chen, Danny" sort="Chen, Danny" uniqKey="Chen D" first="Danny" last="Chen">Danny Chen</name></author><author><name sortKey="Chihara, Shingo" sort="Chihara, Shingo" uniqKey="Chihara S" first="Shingo" last="Chihara">Shingo Chihara</name></author><author><name sortKey="Cohen, Stuart H" sort="Cohen, Stuart H" uniqKey="Cohen S" first="Stuart H." last="Cohen">Stuart H. Cohen</name></author><author><name sortKey="Cunningham, Jennifer" sort="Cunningham, Jennifer" uniqKey="Cunningham J" first="Jennifer" last="Cunningham">Jennifer Cunningham</name></author><author><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name></author><author><name sortKey="Ismail, Saad" sort="Ismail, Saad" uniqKey="Ismail S" first="Saad" last="Ismail">Saad Ismail</name></author><author><name sortKey="Kato, Hideaki" sort="Kato, Hideaki" uniqKey="Kato H" first="Hideaki" last="Kato">Hideaki Kato</name></author><author><name sortKey="Lapadula, Giuseppe" sort="Lapadula, Giuseppe" uniqKey="Lapadula G" first="Giuseppe" last="Lapadula">Giuseppe Lapadula</name></author><author><name sortKey="L Er, Erwan" sort="L Er, Erwan" uniqKey="L Er E" first="Erwan" last="L Er">Erwan L Er</name></author><author><name sortKey="Maeno, Toshitaka" sort="Maeno, Toshitaka" uniqKey="Maeno T" first="Toshitaka" last="Maeno">Toshitaka Maeno</name></author><author><name sortKey="Majumder, Sumit" sort="Majumder, Sumit" uniqKey="Majumder S" first="Sumit" last="Majumder">Sumit Majumder</name></author><author><name sortKey="Massari, Marco" sort="Massari, Marco" uniqKey="Massari M" first="Marco" last="Massari">Marco Massari</name></author><author><name sortKey="Mora Rillo, Marta" sort="Mora Rillo, Marta" uniqKey="Mora Rillo M" first="Marta" last="Mora-Rillo">Marta Mora-Rillo</name></author><author><name sortKey="Mutoh, Yoshikazu" sort="Mutoh, Yoshikazu" uniqKey="Mutoh Y" first="Yoshikazu" last="Mutoh">Yoshikazu Mutoh</name></author><author><name sortKey="Nguyen, Duc" sort="Nguyen, Duc" uniqKey="Nguyen D" first="Duc" last="Nguyen">Duc Nguyen</name></author><author><name sortKey="Verweij, Ewa" sort="Verweij, Ewa" uniqKey="Verweij E" first="Ewa" last="Verweij">Ewa Verweij</name></author><author><name sortKey="Zoufaly, Alexander" sort="Zoufaly, Alexander" uniqKey="Zoufaly A" first="Alexander" last="Zoufaly">Alexander Zoufaly</name></author><author><name sortKey="Osinusi, Anu O" sort="Osinusi, Anu O" uniqKey="Osinusi A" first="Anu O." last="Osinusi">Anu O. 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Green</name></author><author><name sortKey="Lescure, Francois Xavier" sort="Lescure, Francois Xavier" uniqKey="Lescure F" first="François-Xavier" last="Lescure">François-Xavier Lescure</name></author><author><name sortKey="Nicastri, Emanuele" sort="Nicastri, Emanuele" uniqKey="Nicastri E" first="Emanuele" last="Nicastri">Emanuele Nicastri</name></author><author><name sortKey="Oda, Rentaro" sort="Oda, Rentaro" uniqKey="Oda R" first="Rentaro" last="Oda">Rentaro Oda</name></author><author><name sortKey="Yo, Kikuo" sort="Yo, Kikuo" uniqKey="Yo K" first="Kikuo" last="Yo">Kikuo Yo</name></author><author><name sortKey="Quiros Roldan, Eugenia" sort="Quiros Roldan, Eugenia" uniqKey="Quiros Roldan E" first="Eugenia" last="Quiros-Roldan">Eugenia Quiros-Roldan</name></author><author><name sortKey="Studemeister, Alex" sort="Studemeister, Alex" uniqKey="Studemeister A" first="Alex" last="Studemeister">Alex Studemeister</name></author><author><name sortKey="Redinski, John" sort="Redinski, John" uniqKey="Redinski J" first="John" last="Redinski">John Redinski</name></author><author><name sortKey="Ahmed, Seema" sort="Ahmed, Seema" uniqKey="Ahmed S" first="Seema" last="Ahmed">Seema Ahmed</name></author><author><name sortKey="Bernett, Jorge" sort="Bernett, Jorge" uniqKey="Bernett J" first="Jorge" last="Bernett">Jorge Bernett</name></author><author><name sortKey="Chelliah, Daniel" sort="Chelliah, Daniel" uniqKey="Chelliah D" first="Daniel" last="Chelliah">Daniel Chelliah</name></author><author><name sortKey="Chen, Danny" sort="Chen, Danny" uniqKey="Chen D" first="Danny" last="Chen">Danny Chen</name></author><author><name sortKey="Chihara, Shingo" sort="Chihara, Shingo" uniqKey="Chihara S" first="Shingo" last="Chihara">Shingo Chihara</name></author><author><name sortKey="Cohen, Stuart H" sort="Cohen, Stuart H" uniqKey="Cohen S" first="Stuart H." last="Cohen">Stuart H. Cohen</name></author><author><name sortKey="Cunningham, Jennifer" sort="Cunningham, Jennifer" uniqKey="Cunningham J" first="Jennifer" last="Cunningham">Jennifer Cunningham</name></author><author><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name></author><author><name sortKey="Ismail, Saad" sort="Ismail, Saad" uniqKey="Ismail S" first="Saad" last="Ismail">Saad Ismail</name></author><author><name sortKey="Kato, Hideaki" sort="Kato, Hideaki" uniqKey="Kato H" first="Hideaki" last="Kato">Hideaki Kato</name></author><author><name sortKey="Lapadula, Giuseppe" sort="Lapadula, Giuseppe" uniqKey="Lapadula G" first="Giuseppe" last="Lapadula">Giuseppe Lapadula</name></author><author><name sortKey="L Er, Erwan" sort="L Er, Erwan" uniqKey="L Er E" first="Erwan" last="L Er">Erwan L Er</name></author><author><name sortKey="Maeno, Toshitaka" sort="Maeno, Toshitaka" uniqKey="Maeno T" first="Toshitaka" last="Maeno">Toshitaka Maeno</name></author><author><name sortKey="Majumder, Sumit" sort="Majumder, Sumit" uniqKey="Majumder S" first="Sumit" last="Majumder">Sumit Majumder</name></author><author><name sortKey="Massari, Marco" sort="Massari, Marco" uniqKey="Massari M" first="Marco" last="Massari">Marco Massari</name></author><author><name sortKey="Mora Rillo, Marta" sort="Mora Rillo, Marta" uniqKey="Mora Rillo M" first="Marta" last="Mora-Rillo">Marta Mora-Rillo</name></author><author><name sortKey="Mutoh, Yoshikazu" sort="Mutoh, Yoshikazu" uniqKey="Mutoh Y" first="Yoshikazu" last="Mutoh">Yoshikazu Mutoh</name></author><author><name sortKey="Nguyen, Duc" sort="Nguyen, Duc" uniqKey="Nguyen D" first="Duc" last="Nguyen">Duc Nguyen</name></author><author><name sortKey="Verweij, Ewa" sort="Verweij, Ewa" uniqKey="Verweij E" first="Ewa" last="Verweij">Ewa Verweij</name></author><author><name sortKey="Zoufaly, Alexander" sort="Zoufaly, Alexander" uniqKey="Zoufaly A" first="Alexander" last="Zoufaly">Alexander Zoufaly</name></author><author><name sortKey="Osinusi, Anu O" sort="Osinusi, Anu O" uniqKey="Osinusi A" first="Anu O." last="Osinusi">Anu O. Osinusi</name></author><author><name sortKey="Dezure, Adam" sort="Dezure, Adam" uniqKey="Dezure A" first="Adam" last="Dezure">Adam Dezure</name></author><author><name sortKey="Zhao, Yang" sort="Zhao, Yang" uniqKey="Zhao Y" first="Yang" last="Zhao">Yang Zhao</name></author><author><name sortKey="Zhong, Lijie" sort="Zhong, Lijie" uniqKey="Zhong L" first="Lijie" last="Zhong">Lijie Zhong</name></author><author><name sortKey="Chokkalingam, Anand" sort="Chokkalingam, Anand" uniqKey="Chokkalingam A" first="Anand" last="Chokkalingam">Anand Chokkalingam</name></author><author><name sortKey="Elboudwarej, Emon" sort="Elboudwarej, Emon" uniqKey="Elboudwarej E" first="Emon" last="Elboudwarej">Emon Elboudwarej</name></author><author><name sortKey="Telep, Laura" sort="Telep, Laura" uniqKey="Telep L" first="Laura" last="Telep">Laura Telep</name></author><author><name sortKey="Timbs, Leighann" sort="Timbs, Leighann" uniqKey="Timbs L" first="Leighann" last="Timbs">Leighann Timbs</name></author><author><name sortKey="Henne, Ilana" sort="Henne, Ilana" uniqKey="Henne I" first="Ilana" last="Henne">Ilana Henne</name></author><author><name sortKey="Sellers, Scott" sort="Sellers, Scott" uniqKey="Sellers S" first="Scott" last="Sellers">Scott Sellers</name></author><author><name sortKey="Cao, Huyen" sort="Cao, Huyen" uniqKey="Cao H" first="Huyen" last="Cao">Huyen Cao</name></author><author><name sortKey="Tan, Susanna K" sort="Tan, Susanna K" uniqKey="Tan S" first="Susanna K." last="Tan">Susanna K. Tan</name></author><author><name sortKey="Winterbourne, Lucinda" sort="Winterbourne, Lucinda" uniqKey="Winterbourne L" first="Lucinda" last="Winterbourne">Lucinda Winterbourne</name></author><author><name sortKey="Desai, Polly" sort="Desai, Polly" uniqKey="Desai P" first="Polly" last="Desai">Polly Desai</name></author><author><name sortKey="Mera, Robertino" sort="Mera, Robertino" uniqKey="Mera R" first="Robertino" last="Mera">Robertino Mera</name></author><author><name sortKey="Gaggar, Anuj" sort="Gaggar, Anuj" uniqKey="Gaggar A" first="Anuj" last="Gaggar">Anuj Gaggar</name></author><author><name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P." last="Myers">Robert P. Myers</name></author><author><name sortKey="Brainard, Diana M" sort="Brainard, Diana M" uniqKey="Brainard D" first="Diana M." last="Brainard">Diana M. Brainard</name></author><author><name sortKey="Childs, Richard" sort="Childs, Richard" uniqKey="Childs R" first="Richard" last="Childs">Richard Childs</name></author><author><name sortKey="Flanigan, Timothy" sort="Flanigan, Timothy" uniqKey="Flanigan T" first="Timothy" last="Flanigan">Timothy Flanigan</name></author></analytic><series><title level="j">The New England Journal of Medicine</title><idno type="ISSN">0028-4793</idno><idno type="eISSN">1533-4406</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec id="sc_a1"><title>Background</title><p>Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, has shown in vitro activity against SARS-CoV-2.</p></sec><sec id="sc_a2"><title>Methods</title><p>We provided remdesivir on a compassionate-use basis to patients hospitalized with Covid-19, the illness caused by infection with SARS-CoV-2. Patients were those with confirmed SARS-CoV-2 infection who had an oxygen saturation of 94% or less while they were breathing ambient air or who were receiving oxygen support. Patients received a 10-day course of remdesivir, consisting of 200 mg administered intravenously on day 1, followed by 100 mg daily for the remaining 9 days of treatment. This report is based on data from patients who received remdesivir during the period from January 25, 2020, through March 7, 2020, and have clinical data for at least 1 subsequent day.</p></sec><sec id="sc_a3"><title>Results</title><p>Of the 61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). Of the 53 patients whose data were analyzed, 22 were in the United States, 22 in Europe or Canada, and 9 in Japan. At baseline, 30 patients (57%) were receiving mechanical ventilation and 4 (8%) were receiving extracorporeal membrane oxygenation. During a median follow-up of 18 days, 36 patients (68%) had an improvement in oxygen-support class, including 17 of 30 patients (57%) receiving mechanical ventilation who were extubated. A total of 25 patients (47%) were discharged, and 7 patients (13%) died; mortality was 18% (6 of 34) among patients receiving invasive ventilation and 5% (1 of 19) among those not receiving invasive ventilation.</p></sec><sec id="sc_a4"><title>Conclusions</title><p>In this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use remdesivir, clinical improvement was observed in 36 of 53 patients (68%). Measurement of efficacy will require ongoing randomized, placebo-controlled trials of remdesivir therapy. (Funded by Gilead Sciences.)</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ahmed, Seema" sort="Ahmed, Seema" uniqKey="Ahmed S" first="Seema" last="Ahmed">Seema Ahmed</name><name sortKey="Asperges, Erika" sort="Asperges, Erika" uniqKey="Asperges E" first="Erika" last="Asperges">Erika Asperges</name><name sortKey="Bernett, Jorge" sort="Bernett, Jorge" uniqKey="Bernett J" first="Jorge" last="Bernett">Jorge Bernett</name><name sortKey="Brainard, Diana M" sort="Brainard, Diana M" uniqKey="Brainard D" first="Diana M." last="Brainard">Diana M. 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Green</name><name sortKey="Grein, Jonathan" sort="Grein, Jonathan" uniqKey="Grein J" first="Jonathan" last="Grein">Jonathan Grein</name><name sortKey="Henne, Ilana" sort="Henne, Ilana" uniqKey="Henne I" first="Ilana" last="Henne">Ilana Henne</name><name sortKey="Ismail, Saad" sort="Ismail, Saad" uniqKey="Ismail S" first="Saad" last="Ismail">Saad Ismail</name><name sortKey="Kato, Hideaki" sort="Kato, Hideaki" uniqKey="Kato H" first="Hideaki" last="Kato">Hideaki Kato</name><name sortKey="L Er, Erwan" sort="L Er, Erwan" uniqKey="L Er E" first="Erwan" last="L Er">Erwan L Er</name><name sortKey="Lapadula, Giuseppe" sort="Lapadula, Giuseppe" uniqKey="Lapadula G" first="Giuseppe" last="Lapadula">Giuseppe Lapadula</name><name sortKey="Lescure, Francois Xavier" sort="Lescure, Francois Xavier" uniqKey="Lescure F" first="François-Xavier" last="Lescure">François-Xavier Lescure</name><name sortKey="Maeno, Toshitaka" sort="Maeno, Toshitaka" uniqKey="Maeno T" first="Toshitaka" last="Maeno">Toshitaka Maeno</name><name sortKey="Majumder, Sumit" sort="Majumder, Sumit" uniqKey="Majumder S" first="Sumit" last="Majumder">Sumit Majumder</name><name sortKey="Massari, Marco" sort="Massari, Marco" uniqKey="Massari M" first="Marco" last="Massari">Marco Massari</name><name sortKey="Mera, Robertino" sort="Mera, Robertino" uniqKey="Mera R" first="Robertino" last="Mera">Robertino Mera</name><name sortKey="Mora Rillo, Marta" sort="Mora Rillo, Marta" uniqKey="Mora Rillo M" first="Marta" last="Mora-Rillo">Marta Mora-Rillo</name><name sortKey="Mutoh, Yoshikazu" sort="Mutoh, Yoshikazu" uniqKey="Mutoh Y" first="Yoshikazu" last="Mutoh">Yoshikazu Mutoh</name><name sortKey="Myers, Robert P" sort="Myers, Robert P" uniqKey="Myers R" first="Robert P." last="Myers">Robert P. Myers</name><name sortKey="Nguyen, Duc" sort="Nguyen, Duc" uniqKey="Nguyen D" first="Duc" last="Nguyen">Duc Nguyen</name><name sortKey="Nicastri, Emanuele" sort="Nicastri, Emanuele" uniqKey="Nicastri E" first="Emanuele" last="Nicastri">Emanuele Nicastri</name><name sortKey="Oda, Rentaro" sort="Oda, Rentaro" uniqKey="Oda R" first="Rentaro" last="Oda">Rentaro Oda</name><name sortKey="Ohmagari, Norio" sort="Ohmagari, Norio" uniqKey="Ohmagari N" first="Norio" last="Ohmagari">Norio Ohmagari</name><name sortKey="Osinusi, Anu O" sort="Osinusi, Anu O" uniqKey="Osinusi A" first="Anu O." last="Osinusi">Anu O. Osinusi</name><name sortKey="Quiros Roldan, Eugenia" sort="Quiros Roldan, Eugenia" uniqKey="Quiros Roldan E" first="Eugenia" last="Quiros-Roldan">Eugenia Quiros-Roldan</name><name sortKey="Redinski, John" sort="Redinski, John" uniqKey="Redinski J" first="John" last="Redinski">John Redinski</name><name sortKey="Sellers, Scott" sort="Sellers, Scott" uniqKey="Sellers S" first="Scott" last="Sellers">Scott Sellers</name><name sortKey="Shin, Daniel" sort="Shin, Daniel" uniqKey="Shin D" first="Daniel" last="Shin">Daniel Shin</name><name sortKey="Studemeister, Alex" sort="Studemeister, Alex" uniqKey="Studemeister A" first="Alex" last="Studemeister">Alex Studemeister</name><name sortKey="Tan, Susanna K" sort="Tan, Susanna K" uniqKey="Tan S" first="Susanna K." last="Tan">Susanna K. Tan</name><name sortKey="Telep, Laura" sort="Telep, Laura" uniqKey="Telep L" first="Laura" last="Telep">Laura Telep</name><name sortKey="Timbs, Leighann" sort="Timbs, Leighann" uniqKey="Timbs L" first="Leighann" last="Timbs">Leighann Timbs</name><name sortKey="Verweij, Ewa" sort="Verweij, Ewa" uniqKey="Verweij E" first="Ewa" last="Verweij">Ewa Verweij</name><name sortKey="Winterbourne, Lucinda" sort="Winterbourne, Lucinda" uniqKey="Winterbourne L" first="Lucinda" last="Winterbourne">Lucinda Winterbourne</name><name sortKey="Yo, Kikuo" sort="Yo, Kikuo" uniqKey="Yo K" first="Kikuo" last="Yo">Kikuo Yo</name><name sortKey="Zhao, Yang" sort="Zhao, Yang" uniqKey="Zhao Y" first="Yang" last="Zhao">Yang Zhao</name><name sortKey="Zhong, Lijie" sort="Zhong, Lijie" uniqKey="Zhong L" first="Lijie" last="Zhong">Lijie Zhong</name><name sortKey="Zoufaly, Alexander" sort="Zoufaly, Alexander" uniqKey="Zoufaly A" first="Alexander" last="Zoufaly">Alexander Zoufaly</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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